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Aerial view of UCSD campus looking South

Geisel Library - Nobel Laureates at UCSD

Discovery of new atmospheric reaction garners prize

Urey Hall Addition

Pacific Hall

Natural Sciences Building

The crystal structure of a group II intron in the pre-catalytic state

Geisel Library Walk

York Hall

Structure of an inhibitor of hepatitis C virus protein synthesis bound to its target in the viral ribonucleic acid (RNA) genome

ANCA probe staining amyloid plaques derived from Alzheimer’s-related Aβ peptides fluoresces as green and as yellow when derived from prion proteins (PrPSC)

Price Center

Generation of bio-resistive surface coatings on amyloids inhibits harmful protein-amyloid interactions associated with Alzheimer disease

Proposed schematic models of the interfacial binding surface of four different members of the Phospholipase A2 superfamily

Urey Hall and Pacific Hall

Characterization of the "inhibitor binding pocket" in the catalytic domain of the calcium-independent phospholipase A2 with residues within a 5 A raidus of the inhibitor shown

A Crystalline Singlet Phosphinonitrene: a Nitrogen Atom Transfer Agent

Mayer Hall

Drug candidate in orange envelope bound to UPPS

Possible binding modes for phospholipase A2 via its membrane interaction site, another allosteric site, and its catalytic site



News

Amaro Lab's Jamie Schiffer Wins NVIDIA GPU Award at ACS Spring 2015 National Meeting
Jamie Schiffer, a graduate student in the Department of Chemistry and Biochemistry, and member of the Amaro Lab, won the NVIDIA GPU Award for Best GPU Poster at the American Chemical Society (ACS) Spring 2015 National Meeting held in Denver in March. The ACS Division of Computers in Chemistry (COMP) and NVIDIA Corporation determine the recipient of the award based on researchers who have demonstrated outstanding computational chemistry research using a GPU, whether through programming new GPU-accelerated algorithms, existing GPU-accelerated software applications, or both. Jamie’s presentation entitled, 'Entropically Driven CK-ASB9 Interaction: How GPU-enabled Computing Provided Unique Insight into an Intrinsically Disordered 116 kDa Protein Complex', was selected as the grand prize winner from a field of over 130 entrants. Congratulations Jamie!

Rommie Amaro Honored As Woman of the Year Finalist by California State Assembly
UC San Diego Associate Professor of Chemistry and Biochemistry, Rommie Amaro, was honored as a finalist for the 78th District’s 2015 Woman of The Year (WOTY) by California State Assembly Speaker, Toni Atkins. The WOTY event, sponsored by the California Legislative Women's Caucus, celebrates outstanding women in California whose achievements and contributions have made a positive impact on their communities. Professor Amaro’s drug discovery research utilizing cutting-edge computational methods and her BioChemCoRe Outreach Program aimed at cultivating young women scientists were selection factors lauded by Speaker Atkins. Congratulations on this prestigious honor Rommie!

Joseph Lab's Aaron Ward Recipient of NSF Graduate Research Fellowship
We proudly announce that the National Science Foundation has selected Aaron Ward from the Joseph Lab in the Department of Chemistry and Biochemistry as a recipient of the 2015 Graduate Research Fellowship!

Kubiak Research Group's Melissa Clark Receives Area Safety Coordinator-Excellence in Safety Award
Melissa Clark, a graduate student in the Department of Chemistry and Biochemistry and a member of the Kubiak Research Group, was selected as the inaugural recipient of the 'Area Safety Coordinator - Excellence in Safety Award'. The award is in recognition of Melissa’s outstanding contributions towards improving the culture of laboratory safety within the Kubiak Group and on a broader scale throughout the Department of Chemistry & Biochemistry. The Excellence in Safety Award is jointly sponsored by campus Environment, Health & Safety (EH&S) and the Department of Chemistry & Biochemistry. Congratulations Melissa!

Katja Lindenberg Appointed Chancellor's Associates Endowed Chair in Chemistry & Biochemistry
UC San Diego Distinguished Professor of Chemistry and Biochemistry, Katja Lindenberg, has been appointed Chancellor's Associates Endowed Chair in Chemistry and Biochemistry. This distinguished appointment recognizes Department of Chemistry and Biochemistry's Professor Lindenberg for her extraordinary contributions to teaching, research, and academic and community service. Congratulations Katja!

Cliff Kubiak Wins 2015 Basolo Medal for Outstanding Research in Inorganic Chemistry
UC San Diego Distinguished Professor of Chemistry and Biochemistry, Clifford Kubiak, has been awarded the 2015 Fred Basolo Medal for Outstanding Research in Inorganic Chemistry. The prestigious Basolo Medal, established in honor of Northwestern University researcher and educator, the late Dr. Fred Basolo, is awarded annually by the university to a top researcher in the field of inorganic chemistry. Professor Kubiak joins an elite field of Basolo Medal recipients, including three Nobel Prize winners. Congratulations Cliff!

'Journal of Physical Organic Chemistry' Publishes Special Edition Honoring Professor Perrin
The March 2015 issue of the 'Journal of Physical Organic Chemistry' (JPOC) honors Department of Chemistry and Biochemistry Professor Charles Perrin for 50 Years of contributions to Physical Organic Chemistry through his research and teaching at UC San Diego. The 50 Year milestone was celebrated with a symposium held in his honor in September 2013. The JPOC Special Edition adds to the celebration of Professor Perrin's achievements with a collection of commemorative publications and contributions from close friends and colleagues from throughout his career. Of special note is a paper from Charlie's son, David Perrin, Professor of Chemistry at the University of British Columbia. Congratulations Professor Perrin!

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Message from the Chair

Seth M. Cohen, Chair



Faculty Spotlight

View profile for Kim Albizati
Kim Albizati

Chemical Education

View profile for Rommie E. Amaro
Rommie E. Amaro

Computational Chemistry and Biophysics

View profile for Timothy Baker
Timothy Baker

Macromolecular, cryoelectron microscopy and three-dimensional, image-reconstruction techniques.

View profile for Stacey Brydges
Stacey Brydges

Chemical Education: Development of context-rich curriculum; Use of collaborative learning strategies in large lectures; Communication of chemistry

View profile for Michael Burkart
Michael Burkart

Natural product synthesis/biosynthesis, Biological chemistry and enzymology, Metabolic engineering.

View profile for Thomas Bussey
Thomas Bussey

Chemical Education: Visual Literacy in Science, Biochemistry Education, Nano Science Education, K-20 Professional Development, and STEM Career Development

View profile for Seth Cohen
Seth Cohen

Bioinorganic and coordination chemistry. Metalloprotein inhibitors and supramolecular materials.

View profile for Robert Continetti
Robert Continetti

Dissociation dynamics of transient species, three-body reaction dynamics, novel mass-spectrometric methods

View profile for John Crowell
John Crowell

Materials chemistry, surface kinetics of metals/semiconductors, CVD, photo-induced deposition, thin-film spectroscopy.

View profile for Edward Dennis
Edward Dennis

Biochemistry: phospholipase A2, signal transduction in macrophages, lipid maps, prostaglandin regulation, mass spec of lipids and proteins.

View profile for Neal Devaraj
Neal Devaraj

Biomimetic Chemistry, Molecular Imaging, Electrochemistry

View profile for Jack Dixon
Jack Dixon

Protein Tyrosine Phosphatase, Dual=specific Phosphatase, PTEN

View profile for Daniel Donoghue
Daniel Donoghue

Fibroblast Growth Factor Receptors (FGFRs) in Human Cancer

View profile for Josh Figueroa
Josh Figueroa

Inorganic and Organometallic Chemistry: Synthesis, Small Molecule Activation and New Transformations.

View profile for Marye Anne Fox
Marye Anne Fox

Physical organic chemistry; photochemistry; nanoscience of organized arrays.

View profile for Misha Galperin
Misha Galperin

Electron Transport in Condensed Phases. Dissipation and Relaxation Processes. Non-equilibrium Open Quantum Systems. Molecular Electronics.

View profile for Gouri Ghosh
Gouri Ghosh

Biochemistry and biophysics: transcription, signaling, pre-mRNA splicing, mRNA transport, protein-protein, protein-DNA and protein-RNA interactions

View profile for Partho Ghosh
Partho Ghosh

Mechanisms of bacterial and protozoan pathogenesis, and host response against infectious microbes.

View profile for Nathan Gianneschi
Nathan Gianneschi

Bioorganic chemistry, Supramolecular Chemistry, Bionanotechnology, Materials, Synthesis

View profile for Kamil Godula
Kamil Godula

Nanotechnologies for analysis of glycan function during development. Glycomaterials for stem cell-based tissue regeneration.

View profile for Carlos Guerrero
Carlos Guerrero

Chemical synthesis; synthesis-oriented organic chemistry; methods development; synthesis design; total synthesis of natural products.

View profile for Thomas Hermann
Thomas Hermann

RNA as a Drug Target.

View profile for Patricia Jennings
Patricia Jennings

Biophysical chemistry: protein structure, dynamics and folding; 2, 3 and 4D NMR spectroscopy; PCR; equilibrium and kinetic-fluorescence, absorbance and circular dichroism spectroscopies

View profile for Simpson Joseph
Simpson Joseph

Molecular Mechanism of Protein Synthesis

View profile for Judy Kim
Judy Kim

Biophysical chemistry: Spectroscopic studies of membrane protein folding and dynamics

View profile for Elizabeth Komives
Elizabeth Komives

Structure, function, dynamics and thermodynamics of protein-protein interactions: NMR, mass spectrometry and kinetics

View profile for Clifford Kubiak
Clifford Kubiak

Inorganic, materials, and physical chemistry: electron transfer, catalysis, fixation and utilization of carbon dioxide.

View profile for Andrew Kummel
Andrew Kummel

STM/STS of gate oxides on compound semiconductors and adsorbates on organic semiconductor

View profile for Katja Lindenberg
Katja Lindenberg

Theoretical chemical physics: non-equilibrium statistical mechanics; stochastic processes; nonlinear phenomena; complex systems; condensed matter.

View profile for J. Andrew McCammon
J. Andrew McCammon

Statistical mechanics and computational chemistry, with applications to biological systems

View profile for Mario Molina
Mario Molina

Physical Chemistry: Gas Phase Chemical Kinetics and Photochemistry; Chemistry of Atmospheric Aerosols; Air Pollution in Megacities of the Developing World

View profile for Tadeusz Molinski
Tadeusz Molinski

Organic chemistry of marine natural products, synthesis, NMR, and biomedical applications

View profile for Uli Müller
Uli Müller

Evolution of catalytic RNAs, and the Origin of Life

View profile for Joseph O
Joseph O'Connor

Organotransition metal; organic; physical organic; bioorganometallic; synthetic; and inorganic chemistry

View profile for Stanley Opella
Stanley Opella

NMR structural studies of proteins in membranes and other supramolecular assemblies

View profile for Francesco Paesani
Francesco Paesani

Theoretical chemical physics of complex interfaces of relevance to the environment

View profile for Charles Perrin
Charles Perrin

Physical-organic chemistry: stereoelectronic effects; hydrogen bonding; isotope effects; ionic solvation; naked anions; malonic anhydrides

View profile for Robert Pomeroy
Robert Pomeroy

The application of analytical chemistry to forensic, environmental and industrial chemistry, then bridge these experiences into the classroom. This also includes the role technology and instrumentation play in discovery and problem solving.

View profile for Kimberly Prather
Kimberly Prather

Environmental, physical/analytical chemistry: gas/particle processes of tropospheric significance; mass spectrometry; laser-based analysis techniques.

View profile for Arnold Rheingold
Arnold Rheingold

Inorganic chemistry: Small-molecule crystallography, synthesis of transition metal/p-block clusters

View profile for Jeffrey Rinehart
Jeffrey Rinehart

Inorganic, materials, and magnetochemistry

View profile for Michael Sailor
Michael Sailor

Nanomaterials: porous silicon, chemical and biological sensors, biomaterials, electrochemistry

View profile for Barbara Sawrey
Barbara Sawrey

Chemical education: development of computer-based multimedia to assist student learning of complex scientific processes and concepts

View profile for Amitabha Sinha
Amitabha Sinha

Experimental physical chemistry: photochemistry; laser spectroscopy; reaction dynamics of vibrationally excited molecules

View profile for Michael Tauber
Michael Tauber

Physical chemistry; Optical and magnetic spectroscopy; Fundamental studies of charge transport and solvation; Applications to energy conversion and energy storage.

View profile for Susan Taylor
Susan Taylor

Structure, Function, Dynamics, and Localization of PKA as a Prototype for the Protein Kinase Superfamily.

View profile for Akif Tezcan
Akif Tezcan

Bioinorganic and biophysical chemistry; Metalloprotein structure, function and biosynthesis; Biomaterials

View profile for Emmanuel Theodorakis
Emmanuel Theodorakis

Synthetic, Medicinal, Bioorganic and Biological Chemistry, Methods and Strategies in Natural Products Chemistry

View profile for Mark Thiemens
Mark Thiemens

Atmospheric chemistry: physical chemistry of isotope effects; solar system formation

View profile for Navtej Toor
Navtej Toor

Structure and Function of Introns and Retroelements

View profile for Yitzhak Tor
Yitzhak Tor

Ligand-nucleic acid interactions; Antiviral and antibacterial agents; Fluorescent nucleosides and nucleotides; Cellular delivery vehicles

View profile for William Trogler
William Trogler

Inorganic chemistry: polymer chemistry; nanomaterials.

View profile for Roger Tsien
Roger Tsien

Chemical biology; design, synthesis, and application of molecular probes of biological function

View profile for Robert Tukey
Robert Tukey

Environmental toxicology: The role of environmental and chemical toxicants on gene expression

View profile for Elizabeth Villa
Elizabeth Villa

Structural Cell Biology, Cryo-Electron Microscopy, Multiscale modeling

View profile for Wei Wang
Wei Wang

epigenomics, cellular reprogramming, protein recognition, computational biology, systems biology

View profile for John Weare
John Weare

Physical chemistry: calculations of the dynamics of complex systems; theoretical geochemistry

View profile for Haim Weizman
Haim Weizman

Chemical education, Bioorganic chemistry

View profile for Jim Whitesell
Jim Whitesell

Organic chemistry: studies of stereochemistry, both in a molecular and a supramolecular sense.

View profile for Roy Wollman
Roy Wollman

Spatio-temporal signaling control of biological self-organization. Signaling networks in innate immunity. Microscopy; Mathematical modeling; Computational image analysis; Systems Biology.

View profile for Wei Xiong
Wei Xiong

Investigation of charge transfer mechanism in nanomaterials with novel ultrafast spectroscopies

View profile for Jerry Yang
Jerry Yang

Bioorganic Chemistry, Molecular Self-Assembly, Molecular Synthesis, Materials Chemistry, Bionanotechnology


Events and Seminars

04/21/2015 (Tue) at 04:00 PM
Physical/Analytical Seminar
Professor Vijay Pande
Folding@home: How Citizen Science has Lead to Key New Advances in Biophysics and Fighting Disease
04/24/2015 (Fri) at 11:00 AM
Inorganic Seminar
***CANCELLED***Professor Joel Rosenthal***CANCELLED***
TBA
04/24/2015 (Fri) at 01:00 PM
Thesis Defense
Joseph William Kaus
Computer Aided Drug Design: Methods and Applications
04/27/2015 (Mon) at 11:00 AM
Organic Seminar
Professor Adam Braunschweig
The Surface Chemistry Bottleneck
04/29/2015 (Wed) at 01:00 PM
Thesis Defense
Meekyum Olivia Kim
Integrating conformational and protonation equilibria in biomolecular modeling
04/30/2015 (Thu) at 04:00 PM
Special Seminar
2015 Pfizer Lecture: Professor Tobias Ritter
Late-Stage Fluorination for PET Imaging
05/01/2015 (Fri) at 10:00 AM
Thesis Defense
Marcel Michael Hetu
Sensitive Nonlinear Laser-Based Spectroscopic Studies of Chemical and Biological Agents for Biomedical and Security Applications
More....