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Aerial view of UCSD campus looking South

Geisel Library - Nobel Laureates at UCSD

Discovery of new atmospheric reaction garners prize

Urey Hall Addition

Pacific Hall

Natural Sciences Building

The crystal structure of a group II intron in the pre-catalytic state

Geisel Library Walk

York Hall

Structure of an inhibitor of hepatitis C virus protein synthesis bound to its target in the viral ribonucleic acid (RNA) genome

ANCA probe staining amyloid plaques derived from Alzheimer’s-related Aβ peptides fluoresces as green and as yellow when derived from prion proteins (PrPSC)

Price Center

Generation of bio-resistive surface coatings on amyloids inhibits harmful protein-amyloid interactions associated with Alzheimer disease

Proposed schematic models of the interfacial binding surface of four different members of the Phospholipase A2 superfamily

Urey Hall and Pacific Hall

Characterization of the "inhibitor binding pocket" in the catalytic domain of the calcium-independent phospholipase A2 with residues within a 5 A raidus of the inhibitor shown

A Crystalline Singlet Phosphinonitrene: a Nitrogen Atom Transfer Agent

Mayer Hall

Drug candidate in orange envelope bound to UPPS

Possible binding modes for phospholipase A2 via its membrane interaction site, another allosteric site, and its catalytic site



News

Pharmaceutical Companies to Share Data for Drug Design via New UC San Diego-Led Resource
Pharmaceutical companies will collaborate with researchers at UC San Diego to provide previously unreleased proprietary data for drug discovery through a new $3.7 million effort funded by the National Institutes of Health. The project, which is led by principal investigators Rommie Amaro & Victoria Feher from the Department of Chemistry & Biochemistry and Dr. Michael Gilson from the Skaggs School of Pharmacy and Pharmaceutical Sciences, includes a major subcontract to Rutgers University, directed by Dr. Stephen K. Burley of the Research Collaboratory for Structural Bioinformatics Protein Data Bank.

Perrin Lab Produces First "Naked" Aryl Anion in Solution
Professor Perrin and graduate student, Gabriel J. Reyes-Rodriguez have discovered the first "naked" aryl anion in solution-a carbanion not linked to counterions or stabilized by hydrogen bonding. Small naked carbanions have been created and studied in the gas phase before, but never in solution; the discovery provides a previously unknown type of species in solution for testing the relation between molecular structure and reactivity.

William E. Moerner, Former UCSD Chemist Wins Nobel Prize
William E. Moerner, one of three scientists who this week were named winners of the 2014 Nobel Prize in Chemistry, first applied his Nobel Prize-winning discovery to biological problems while working in the basement of Urey Hall as a professor of chemistry and biochemistry at UC San Diego from 1995 to 1998.

Assoc. Prof. Nathan Gianneschi Wins Excellence in Postdoc Scholar Mentoring Award
We are pleased to announce the recipients of the 2014-15 Chancellors Award for Excellence in Postdoctoral Scholar Mentoring and Outstanding Postdoctoral Scholar. The Chancellors Award for Excellence in Postdoctoral Scholar Mentoring recognizes faculty mentors who serve as effective advisors, advocates,role models and colleagues to their postdoctoral trainees, and who promote high standards of professionalism and research integrity. This years recipients are among others, one of our own Associate Professor Nathan Gianneschi. Ph.D. of Chemistry and Biochemistry They will be honored on Friday, September 26, 2014 at the Postdoc Appreciation Luncheon and Award Ceremony in Price Center Ballroom, 12:00-2:00 pm. Please join us in congratulating this years recipients and celebrating their achievements.

Associate Prof. Rommie Amaro is Awarded $9 Million to Fund National Biomedical Computation Resource
Associate Professor Rommie Amaro was awarded $9 million in funding by the National Institutes of Health to continue connecting Biomedical Scientists with the latest in computational chemistry and information technologies.

Prof. Charles Perrin to be Awarded James Flack Norris Award
Prof. Charles L. Perrin has been named the recipient of the 2015 James Flack Norris Award in Physical Organic Chemistry, sponsored by the Northeastern Division of the American Chemical Society. The award is based on "his insight, rigorous analysis, and understanding of mechanisms and reactive intermediates". The formal presentation will take place on Tuesday, March 24, 2015, during the 249th ACS National Meeting in Denver, CO.

Sugar mimic guides stem cells toward neural fate
Long chains of sugars dangle from proteins on the surface of embryonic stem cells and play an important role in how the cells develop into specific cell types. Kamil Godula, an assistant professor of chemistry and biochemistry, and his research group have now synthesized a molecular mimic of these sugar-decorated proteins that helps direct mouse embryonic stem cells down the path toward nerve cells they report in the Journal of the American Chemical Society. The researchers hope others can easily adopt their method to explore how these cell surface sugars influence stem cell differentiation. Read more about these molecular mimics in Chemical and Engineering News.

2014/15 GAANN Fellows Selected
It is with pleasure that we announce our selections for the 2014-15 GAANN Fellowship Program: Doug Agnew, Melissa Clark, Matt Del Bel, Patrycja Hopkins, John Kim, Katherine Nadler, Megan Stone, Holly Dembinski, Kara Finzel, Michelle Lacoske, Clare Leguyader, Greg Medders, Ignacio Lopez-Pena, and David Ruiz.

Department of Chemistry and Biochemistry Annual Outstanding Dissertation Award Recipients Announced
The Department of Chemistry and Biochemistry proudly announces this years recipients of the 2013-14 Outstanding Dissertation Award: Jeff Brodin (Tezcan Lab), Nicholas Brunn (Hermann Lab), and Miao-Ping Chien (Gianneschi Lab).

Department of Chemistry and Biochemistry Affiliates Receive ACS DIC Young Investigator Award
Congratulations to the Chemistry and Biochemistry Department recipients of the ACS Division of Inorganic Chemistry Young Investigator Award!

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Message from the Chair

Seth M. Cohen, Chair



Faculty Spotlight

View profile for Kim Albizati
Kim Albizati

Chemical Education                                                 

View profile for Rommie Amaro
Rommie Amaro

Computational Chemistry and Biophysics

View profile for Timothy Baker
Timothy Baker

Macromolecular, cryoelectron microscopy and three-dimensional, image-reconstruction techniques.

View profile for Timothy Bertram
Timothy Bertram

Experimental Atmospheric Chemistry

View profile for Guy Bertrand
Guy Bertrand

                                                 

View profile for Stacey Brydges
Stacey Brydges

Chemical Education: Development of context-rich curriculum; Use of collaborative learning strategies in large lectures; Communication of chemistry

View profile for Michael Burkart
Michael Burkart

Natural product synthesis/biosynthesis, Biological chemistry and enzymology, Metabolic engineering.

View profile for Seth Cohen
Seth Cohen

Bioinorganic and coordination chemistry. Metalloprotein inhibitors and supramolecular materials.

View profile for Robert Continetti
Robert Continetti

Dissociation dynamics of transient species, three-body reaction dynamics, novel mass-spectrometric methods

View profile for John Crowell
John Crowell

Materials chemistry, surface kinetics of metals/semiconductors, CVD, photo-induced deposition, thin-film spectroscopy.

View profile for Edward Dennis
Edward Dennis

Biochemistry: phospholipase A2, signal transduction in macrophages, lipid maps, prostaglandin regulation, mass spec of lipids and proteins.

View profile for Neal Devaraj
Neal Devaraj

Biomimetic Chemistry, Molecular Imaging, Electrochemistry

View profile for Jack Dixon
Jack Dixon

Protein Tyrosine Phosphatase, Dual=specific Phosphatase, PTEN

View profile for Daniel Donoghue
Daniel Donoghue

Fibroblast Growth Factor Receptors (FGFRs) in Human Cancer

View profile for Pieter Dorrestein
Pieter Dorrestein

Biochemistry, Chemical Biology, Mass spectrometry; Harvesting genomic information for therapeutics.

View profile for Joshua Figueroa
Joshua Figueroa

Inorganic and Organometallic Chemistry: Synthesis, Small Molecule Activation and New Transformations.

View profile for Marye Anne Fox
Marye Anne Fox

Physical organic chemistry; photochemistry; nanoscience of organized arrays.

View profile for Michael Galperin
Michael Galperin

Electron Transport in Condensed Phases. Dissipation and Relaxation Processes. Non-equilibrium Open Quantum Systems. Molecular Electronics.

View profile for Gourisankar Ghosh
Gourisankar Ghosh

Biochemistry and biophysics: transcription, signaling, pre-mRNA splicing, mRNA transport, protein-protein, protein-DNA and protein-RNA interactions

View profile for Gourisankar Ghosh
Gourisankar Ghosh

Biochemistry and biophysics: transcription, signaling, pre-mRNA splicing, mRNA transport, protein-protein, protein-DNA and protein-RNA interactions

View profile for Partho Ghosh
Partho Ghosh

Mechanisms of bacterial and protozoan pathogenesis, and host response against infectious microbes.

View profile for Nathan Gianneschi
Nathan Gianneschi

Bioorganic chemistry, Supramolecular Chemistry, Bionanotechnology, Materials, Synthesis

View profile for Carlos Guerrero
Carlos Guerrero

Chemical synthesis; synthesis-oriented organic chemistry; methods development; synthesis design; total synthesis of natural products.

View profile for Thomas Hermann
Thomas Hermann

RNA as a Drug Target.                                                 

View profile for Alexander Hoffmann
Alexander Hoffmann

Biochemistry: signaling, transcription, computational network; stress and immune responses, apoptosis, proliferation

View profile for Patricia Jennings
Patricia Jennings

Biophysical chemistry: protein structure, dynamics and folding; 2, 3 and 4D NMR spectroscopy; PCR; equilibrium and kinetic-fluorescence, absorbance and circular dichroism spectroscopies

View profile for Simpson Joseph
Simpson Joseph

Molecular Mechanism of Protein Synthesis

View profile for Judy Kim
Judy Kim

Biophysical chemistry: Spectroscopic studies of membrane protein folding and dynamics

View profile for Elizabeth Komives
Elizabeth Komives

Structure, function, dynamics and thermodynamics of protein-protein interactions: NMR, mass spectrometry and kinetics

View profile for Clifford Kubiak
Clifford Kubiak

Inorganic, materials, and physical chemistry: electron transfer, catalysis, fixation and utilization of carbon dioxide.

View profile for Andrew Kummel
Andrew Kummel

STM/STS of gate oxides on compound semiconductors and adsorbates on organic semiconductor

View profile for Katja Lindenberg
Katja Lindenberg

Theoretical chemical physics: non-equilibrium statistical mechanics;stochastic processes; nonlinear phenomena; complex systems; condensed matter.

View profile for Douglas Magde
Douglas Magde

Experimental physical chemistry: photochemistry and photobiophysics; pico- and femtosecond lasers

View profile for J. Andrew McCammon
J. Andrew McCammon

Statistical mechanics and computational chemistry, with applications to biological systems

View profile for Mario Molina
Mario Molina

Physical Chemistry: Gas Phase Chemical Kinetics and Photochemistry; Chemistry of Atmospheric Aerosols; Air Pollution in Megacities of the Developing World

View profile for Tadeusz Molinski
Tadeusz Molinski

Organic chemistry of marine natural products, synthesis, NMR, and biomedical applications

View profile for Ulrich Muller
Ulrich Muller

Evolution of catalytic RNAs, and the Origin of Life

View profile for Joseph O
Joseph O'Connor

Organotransition metal; organic; physical organic; bioorganometallic; synthetic; and inorganic chemistry

View profile for Stanley Opella
Stanley Opella

NMR structural studies of proteins in membranes and other supramolecular assemblies

View profile for Francesco Paesani
Francesco Paesani

Theoretical chemical physics of complex interfaces of relevance to the environment

View profile for Charles Perrin
Charles Perrin

Physical-organic chemistry: stereoelectronic effects; hydrogen bonding; isotope effects; ionic solvation

View profile for Robert Pomeroy
Robert Pomeroy

The application of analytical chemistry to forensic, environmental and industrial chemistry, then bridge these experiences into the classroom. This also includes the role technology and instrumentation play in discovery and problem solving.

View profile for Kimberly Prather
Kimberly Prather

Environmental, physical/analytical chemistry: gas/particle processes of tropospheric significance; mass spectrometry; laser-based analysis techniques.

View profile for Arnold Rheingold
Arnold Rheingold

Inorganic chemistry: Small-molecule crystallography, synthesis of transition metal/p-block clusters

View profile for Michael Sailor
Michael Sailor

Nanomaterials: porous silicon, chemical and biological sensors, biomaterials, electrochemistry

View profile for Barbara Sawrey
Barbara Sawrey

Chemical education: development of computer-based multimedia to assist student learning of complex scientific processes and concepts

View profile for Amitabha Sinha
Amitabha Sinha

Experimental physical chemistry: photochemistry; laser spectroscopy; reaction dynamics of vibrationally excited molecules

View profile for Michael Tauber
Michael Tauber

Physical chemistry; Optical and magnetic spectroscopy; Fundamental studies of charge transport and solvation; Applications to energy conversion and energy storage.

View profile for Susan Taylor
Susan Taylor

Structure, Function, Dynamics, and Localization of PKA as a Prototype for the Protein Kinase Superfamily.

View profile for Akif Tezcan
Akif Tezcan

Bioinorganic and biophysical chemistry; Metalloprotein structure, function and biosynthesis; Biomaterials

View profile for Emmanouil Theodorakis
Emmanouil Theodorakis

Synthetic, Medicinal, Bioorganic and Biological Chemistry, Methods and Strategies in Natural Products Chemistry

View profile for Mark Thiemens
Mark Thiemens

Atmospheric chemistry: physical chemistry of isotope effects; solar system formation

View profile for Navtej Toor
Navtej Toor

Structure and Function of Introns and Retroelements

View profile for Yitzhak Tor
Yitzhak Tor

Ligand-nucleic acid interactions; Antiviral and antibacterial agents; Fluorescent nucleosides and nucleotides; Cellular delivery vehicles

View profile for William Trogler
William Trogler

Inorganic chemistry: polymer chemistry; nanomaterials.

View profile for Roger Tsien
Roger Tsien

Chemical biology; design, synthesis, and application of molecular probes of biological function

View profile for Robert Tukey
Robert Tukey

Environmental toxicology: The role of environmental and chemical toxicants on gene expression

View profile for Hector Viadiu
Hector Viadiu

Laboratory of Structural Biochemistry: X-ray Crystallography and Cryo-Electron Microscopy of DNA Binding Proteins and Membrane Proteins

View profile for Wei Wang
Wei Wang

Inference of gene regulatory networks and determination of protein specificity

View profile for John Weare
John Weare

Physical chemistry: calculations of the dynamics of complex systems; theoretical geochemistry

View profile for Haim Weizman
Haim Weizman

Chemical education, Bioorganic chemistry

View profile for James Whitesell
James Whitesell

Organic chemistry: studies of stereochemistry, both in a molecular and a supramolecular sense.

View profile for Roy Wollman
Roy Wollman

Spatio-temporal signaling control of biological self-organization. Signaling networks in innate immunity. Microscopy; Mathematical modeling; Computational image analysis; Systems Biology.

View profile for Jerry Yang
Jerry Yang

Bioorganic Chemistry, Molecular Self-Assembly, Molecular Synthesis, Materials Chemistry, Bionanotechnology


Events and Seminars

Oct 27 2014 at 11:00 AM
Organic Seminar
Professor Peng Wu
Visualize Glycans in Living Systems and Human Samples Using Bioorthogonal Chemistry
Oct 27 2014 at 1:00PM
Thesis Defense
Corinne Allen
Tolerance of Metal-Organic Frameworks to Functionalization
Oct 30 2014 at 12:00 pm
Biochemistry Seminar
Professor Klemens Hertel
Predicting Alternative pre-mRNA Splicing Behaviors: Modes of Regulations and the Discovery of Splice Altering SNPs
Oct 30 2014 at 4:00 PM
Biochemistry Seminar
Professor Gail Fannucci
Elucidating Mechanisms of Drug Resistance in HIV -1 Protease via Magnetic Resonance Spectroscopy.
Oct 31 2014 at 11:00 AM
Department Colloquia
Professor Michael Sailor
In Vivo Imaging and Drug Delivery With Targeted Silicon Nanoparticles
Nov 3 2014 at 11:00 AM
Organic Seminar
Professor Larry E. Overman
Rearranged Spongian Diterpenes: Linking Chiral Rings at Stereocenters
Nov 3 2014 at 4:00 PM
Department Colloquia
Professor Francesco Paesani
TBA
Nov 4 2014 at 4:00 PM
Special Seminar
*Pfizer Drug Discovery and Development Symposium Series* Dr. Stephan Caron
Developing a Commercial Drug Substance Process
More....